A new role of growth hormone and insulin-like growth factor receptor type 1 in neonatal inflammatory nociception: response to commentary
نویسنده
چکیده
The authors provide a nice summary of our recent report on how growth hormone (GH) regulates neonatal inflammatory pain.We still need to understand how GH is downregulated during peripheral injury and how this reduction causes a paradoxical increase in sensory neuron IGFr1. To clarify, IGF-1 was not statistically increased in the skin as suggested. Furthermore, although not confirmed in vivo, in vitro data suggest direct effects of GH on neuronal IGFr1 expression. Nevertheless, this article highlights the next logical steps we are currently pursuing to elucidate mechanisms by which GH may provide neonatal analgesia.
منابع مشابه
A new role of growth hormone and insulin growth factor receptor type 1 in neonatal inflammatory nociception
Growth hormone (GH) and insulin growth factor 1 (IGF1) are implicated in nociceptive processing; it has been reported that the latter participates in neonatal inflammatory nociception. In the target article, the authors propose that local inflammation evoked by carrageenan administration in mice produces a decrease in the local GH levels and an increment of IGF1 receptors type 1 expression, thi...
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